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NIR Raman Spectroscopy For Biomedical Applications
The Raman spectrograph consists of a diode laser (785 nm), holographic super notch filter and a CCD spectrograph system. Extensive studies were carried out on Raman spectra of body fluids, and tissue samples.
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Raman Spectroscopy For Study Of Radiation Damage
The research program involves the study of radiation effect on animals (mice) brain by various spectroscopic methods in order to
understand mechanisms of interaction of nuclear radiation with biological systems and subsequent damages / changes that result from radiation exposure. Laser Raman and laser induced fluorescence spectra of cells and cell components (membranes, proteins, DNA etc.) of different parts of brain will be recorded. Laser induced fluorescence spectrum will interpreted in terms of morphological changes as well as chemical composition. Raman spectra will be used to identify structural changes produced in various
biochemical systems like proteins, lipids, etc. On the basis of these studies, a model for the interaction of radiation and subsequent changes in the brain cells will be formulated.
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Development of Laser Spectroscopy Methods for Early Diagnosis of Neoplasia
The main objective of the project is development of ultra sensitive LIF methods for detection and quantitation of tumor associated enzymes, hormones or other tumor markers mainly in serum, pleural fluid, ascitic fluid and cerebrospinal fluid (CSF) metabolic products and also in clinical samples obtained through fine needle aspiration, cytologic smears and brush biopsies. The LIF system consists of a CW UV laser (Intra-cavity frequency doubled Ar ion laser) HPLC and Spectrograph CCD system. |
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Laser Spectroscopy Techniques for Clinical Application.
The main objectives are development of experimental set up of Raman, fluorescence and photoacoustic spectroscopy techniques for optical pathology. A Nd.YAG MOPO laser system is using for fluorescence and photoacoustic studies. |
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